- Sandwich Shop Restaurants, Williamsport
- Scaffolding & Aerial Lifts, Williamsport
- Security & Surveillance System & Equipment, Williamsport
- Security Brokers & Dealers, Williamsport
- Security Services, Williamsport
- Senior Citizens Service & Health Organizations, Williamsport
- Septic Tank Installation & Repair, Williamsport - Septic Systems
- Septic Tank Pumping & Cleaning, Williamsport - Septic Systems
- Septic Tanks & Septic Systems Contractors, Williamsport - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Williamsport - Wholesale, Dealers & Suppliers
- Service Establishment Supplies & Equipment, Williamsport
- Sewing Contractors, Williamsport
- Shopping & Shopping Services, Williamsport
- Siding Contractors, Williamsport - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
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- Siding Materials, Williamsport
- Snacks & Desserts, Williamsport
- Snow Removal Services, Williamsport - Snow Plow Service
- Social Services & Welfare, Williamsport
- Societies & Foundation Associations, Williamsport
- Specialty Stores, Williamsport
- Sporting Goods Stores, Williamsport
- Sprinkler Alarm Systems, Williamsport - Fire Sprinkler Systems
- Stadiums, Arenas, Coliseums & Athletic Fields, Williamsport
- Steel Manufacturers, Williamsport
- Stocks & Bond Brokers, Williamsport
- Stone & Rock Quarry, Williamsport - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
- Sweepers & Scrubbers Industrial, Williamsport - Sweeping Service
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