- U-Haul Truck Rental, Frederick - U-Haul Moving
- U-Haul Trucks, Frederick - Uhaul Truck Rental
- U.S. Postal Service, Frederick
- Underground Utility Locating Service, Frederick
- Uniforms, Frederick
- Uniforms, Work Clothes & Safety Clothing, Frederick
- Unitarian Universalist Churches, Frederick
- United States Marines, Frederick
- Unity Church, Frederick
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- Urologists, Frederick - Urology Doctors, Physicians & Surgeons
- Used Book Stores, Frederick - New & Rare Books
- Used Cars, Truck, Van & SUV Car Dealerships, Frederick
- Used Merchandise, Resale Shops & Thrift Stores, Frederick
- Utilities, Frederick
- Utilities Contractors, Frederick
- Utility & Waste Management Services, Frederick
- Utility Installation Contractors, Frederick
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